Fragment based

• CRem: open-source Python framework to generate chemical structures using a fragment-based approach
  
• FASMIFRA: Generate molecules fast from a molecular training set while also doing training-set distribution matching
  
• FraHMT: FraHMT: A Fragment-Oriented Heterogeneous Graph Molecular Generation Model for Target Proteins
  
• MiCaM (De Novo Molecular Generation via Connection-aware Motif Mining): Introduces a novel approach for de novo molecular generation by mining connection-aware motifs from molecular structures, aiming to enhance molecule generation processes.
  
• Molecule Generator: A fragment-based molecular generation method (standalone)