Bioisosteres ShEPhERD: Diffusing shape, electrostatics, and pharmacophores for bioisosteric drug design Database Mining Approach SwissBioisostere: provide bioisosteres for a molecular fragment selected by a medicinal chemist Machine-Learning DeepBioisostere: DeepBioisostere: Discovering Bioisosteres with Deep Learning for a Fine Control of Multiple Molecular Properties Modof: Molecule Optimization via Fragment-based Generative Models